Gather all your ingredients and equipment.

Fill a serving glass with ice cubes.

In a shaker, combine vodka, lime juice, grapefruit juice, simple syrup, and cranberry juice.

Add ice to the shaker, secure the lid, and shake vigorously for about 15 seconds.

Using a strainer, pour the mixture into the ice-filled glass.

Add a fresh lime slice on the rim of the glass for garnish.

Serve immediately.